PlayOnLinux is a graphical front-end for Wine which automatically creates
a prefix for the application you're trying to install. It manages
its own wine versions internally, meaning you only have to have some
version of Wine already already installed as a base and PlayOnLinux
will automatically download and use whatever Wine version is necessary
(which can also be specified by the user in the case of manual, unscripted
installations). POL supports the use of installation scripts which are
used to automatically install an application and configure Wine to work
with that application. Dozens of official scripts for various games and
software already exist, and the POL website has tutorials to instruct
users on writing their own.

For maximum performance and compatibility, PlayOnLinux should be run on
a 32-bit system, or on a 64-bit system enabled for multilib, and 32-bit
graphic libraries should be available.