Package: visit
Title: Vaccine Phase I Design with Simultaneous Evaluation of
        Immunogenicity and Toxicity
Version: 2.2
Author: Zilu Wang [aut, cre]
    Chenguang Wang [aut, cre]
    Gary L Rosner [aut]
    Richard BS Roden  [aut]
    Trustees of Columbia University [cph] (tools/make_cpp.R, R/stanmodels.R)
Maintainer: Chenguang Wang <cwang68@jhmi.edu>
Description: 
    Phase I clinical trials are the first step in drug development to test
    a new drug or drug combination on humans. Typical designs of Phase I 
    trials use toxicity as the primary endpoint and aim to find the maximum 
    tolerable dosage. However, these designs are poorly applicable for the 
    development of cancer therapeutic vaccines because the expected safety 
    concerns for these vaccines are not as much as cytotoxic agents. The 
    primary objectives of a cancer therapeutic vaccine phase I trial thus 
    often include determining whether the vaccine shows biologic activity 
    and the minimum dose necessary to achieve a full immune or even clinical 
    response. This package implements a Bayesian Phase I cancer vaccine
    trial design that allows simultaneous evaluation of safety and
    immunogenicity outcomes. See Wang et al. (2019) <DOI:10.1002/sim.8021>
    for further details.
Depends: methods, R (>= 3.5.0), rstan (>= 2.19.2), Rcpp (>= 1.0.2)
License: GPL (>= 3)
LinkingTo: BH (>= 1.69.0-1), Rcpp (>= 1.0.2), rstan (>= 2.14),
        RcppEigen (>= 0.3.3.5.0), StanHeaders (>= 2.18.1-10),
        RcppParallel (>= 5.0.2)
Imports: sqldf (>= 0.4), parallel (>= 3.2), rstantools (>= 2.1.1),
        RcppParallel (>= 5.0.2)
Encoding: UTF-8
RoxygenNote: 7.2.3
SystemRequirements: GNU make
NeedsCompilation: yes
Suggests: knitr, shiny, rmarkdown, pander, xtable
VignetteBuilder: knitr
Packaged: 2023-08-08 01:28:04 UTC; zilu
Repository: CRAN
Date/Publication: 2023-08-09 10:30:02 UTC
Built: R 4.5.0; aarch64-apple-darwin20; 2025-01-22 15:32:59 UTC; unix
Archs: visit.so.dSYM
