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*                           pheno.mlxtran                                      *
*                           May 16, 2022 at 20:43:58                           *
*                           Monolix version : 2021R1                           *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
cl_pop    :                        0.00671  0.000503      7.49
v_pop     :                           1.41    0.0786      5.57

Standard Deviation of the Random Effects -
omega_cl  :                          0.484    0.0609      12.6
omega_v   :                          0.409    0.0412      10.1

Correlations -----------------------------
corr_v_cl :                          0.903    0.0706      7.82

Error Model Parameters -------------------
add__err  :                           2.73     0.245      8.96

Elapsed time (seconds):       14
CPU time     (seconds):       33
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
           min        Q1    median        Q3       max
cl :   0.00243   0.00499   0.00611   0.00823     0.024
v  :     0.698      1.07      1.35      1.64      4.63

Elapsed time (seconds):      1.8
CPU time     (seconds):      4.1
Iterations:       63 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
           min        Q1    median        Q3       max
cl :   0.00236   0.00501   0.00623   0.00817    0.0257
v  :     0.693      1.07      1.36      1.69      4.68

Elapsed time (seconds):     0.14
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
   cl_pop         1
    v_pop   0.63905         1
 omega_cl         0         0         1
corr_v_cl         0         0  0.026745         1
  omega_v         0         0    0.4256  0.099379         1
 add__err         0         0  -0.11713   0.40148 -0.065365         1

                               min       max   max/min
Eigen values           :      0.36       1.6       4.5

Elapsed time (seconds):    0.044
CPU time     (seconds):        0

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :         975.22
Akaike Information Criteria               (AIC) :         987.22
Corrected Bayesian Information Criteria  (BICc) :        1002.58
Bayesian Information Criteria             (BIC) :         999.69

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

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DATASET INFORMATION
Number of individuals: 59
Number of observations (DV): 155
Number of doses: 589

