********************************************************************************
*                           pbpk.mlxtran                                       *
*                            at                                                *
*                           Monolix version : 2021R1                           *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
KbBR_pop    :                       0.0649   0.00168       2.6
KbMU_pop    :                         2.91    0.0541      1.86
KbAD_pop    :                         12.5     0.509      4.08
CLint_pop   :                     3.43e+03       257      7.48
KbBO_pop    :                         1.01  0.000584    0.0577
KbRB_pop    :                         2.89    0.0873      3.02

Standard Deviation of the Random Effects -
omega_CLint :                        0.783    0.0542      6.93

Error Model Parameters -------------------
lnorm__sd   :                        0.433   0.00637      1.47

Elapsed time (seconds):  2.5e+03
CPU time     (seconds):  7.1e+03
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
              min        Q1    median        Q3       max
KbBR  :    0.0649    0.0649    0.0649    0.0649    0.0649
KbMU  :      2.91      2.91      2.91      2.91      2.91
KbAD  :      12.5      12.5      12.5      12.5      12.5
CLint :       749  1.87e+03  3.59e+03  6.43e+03  2.12e+04
KbBO  :      1.01      1.01      1.01      1.01      1.01
KbRB  :      2.89      2.89      2.89      2.89      2.89

Elapsed time (seconds):      8.6
CPU time     (seconds):       27
Iterations:       87 (Autostop)

 -------------------------------------------------------------------------------


Estimation of the individual parameters by Conditional Mode --------------------
              min        Q1    median        Q3       max
KbBR  :    0.0649    0.0649    0.0649    0.0649    0.0649
KbMU  :      2.91      2.91      2.91      2.91      2.91
KbAD  :      12.5      12.5      12.5      12.5      12.5
CLint :       734  1.89e+03  3.55e+03  6.18e+03  1.95e+04
KbBO  :      1.01      1.01      1.01      1.01      1.01
KbRB  :      2.89      2.89      2.89      2.89      2.89

Elapsed time (seconds):      1.1
CPU time     (seconds):        4

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
   KbBR_pop         1
   KbMU_pop  -0.02104         1
   KbAD_pop  0.024256   0.12148         1
  CLint_pop -0.052377  0.043676   -0.1159         1
   KbBO_pop 0.0066526   0.24593  0.047293-0.0024444         1
   KbRB_pop -0.035648  -0.23563 -0.027681 -0.004607  -0.36007         1
omega_CLint         0         0         0         0         0         0         1
  lnorm__sd         0         0         0         0         0         0 -0.015173         1

                               min       max   max/min
Eigen values           :      0.64       1.6       2.5

Elapsed time (seconds):     0.89
CPU time     (seconds):        0

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :       25031.48
Akaike Information Criteria               (AIC) :       25047.48
Corrected Bayesian Information Criteria  (BICc) :       25090.83
Bayesian Information Criteria             (BIC) :       25069.78

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 120
Number of observations (DV): 2427
Number of doses: 198

