The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
| Version: | 1.0 |
| Depends: | R (≥ 3.6) |
| Imports: | testit, ResourceSelection |
| Published: | 2022-12-15 |
| DOI: | 10.32614/CRAN.package.HybridDesign |
| Author: | Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut] |
| Maintainer: | Heng Zhou <heng.zhou at merck.com> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| CRAN checks: | HybridDesign results |
| Reference manual: | HybridDesign.pdf |
| Package source: | HybridDesign_1.0.tar.gz |
| Windows binaries: | r-devel: HybridDesign_1.0.zip, r-release: HybridDesign_1.0.zip, r-oldrel: HybridDesign_1.0.zip |
| macOS binaries: | r-devel (arm64): HybridDesign_1.0.tgz, r-release (arm64): HybridDesign_1.0.tgz, r-oldrel (arm64): HybridDesign_1.0.tgz, r-devel (x86_64): HybridDesign_1.0.tgz, r-release (x86_64): HybridDesign_1.0.tgz, r-oldrel (x86_64): HybridDesign_1.0.tgz |
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