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*                          x-001-monolix.mlxtran                               *
*                          June 10, 2022 at 21:11:59                           *
*                          Monolix version : 2021R1                            *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)
CIRC0_pop   :                         7.62     0.409      5.38
MTT_pop     :                          121       5.5      4.55
SLOPU_pop   :                         32.9      3.11      9.47
GAMMA_pop   :                        0.229   0.00135      0.59

Standard Deviation of the Random Effects -
omega_CIRC0 :                        0.325    0.0395      12.2
omega_MTT   :                        0.244    0.0405      16.6
omega_SLOPU :                        0.375    0.0781      20.8

Error Model Parameters -------------------
prop__err   :                         0.23    0.0197      8.59

Elapsed time (seconds):  1.8e+02
CPU time     (seconds):  4.7e+02
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
              min        Q1    median        Q3       max
CIRC0 :      3.15      6.43      7.44      9.43      12.9
MTT   :      65.7       108       126       140       191
SLOPU :      18.9      30.4      34.1      41.8      69.2
GAMMA :     0.229     0.229     0.229     0.229     0.229

Elapsed time (seconds):      1.2
CPU time     (seconds):        2

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
  CIRC0_pop         1
    MTT_pop  0.065641         1
  SLOPU_pop   0.17831   0.18014         1
  GAMMA_pop -0.013677  0.050466  0.043628         1
omega_CIRC0  0.014827  0.022486  0.041253 -0.028467         1
  omega_MTT  0.026902  0.097509   0.13927  0.017285-0.0086716         1
omega_SLOPU -0.020912  -0.10079  -0.21037-0.0095074 -0.060046  -0.13471         1
  prop__err -0.092934 -0.054695  -0.26614  -0.02718 -0.045343  -0.16115 -0.030924         1

                               min       max   max/min
Eigen values           :      0.62       1.6       2.6

Elapsed time (seconds):       13
CPU time     (seconds):       33
Iterations:      100 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         776.77
Akaike Information Criteria               (AIC) :         792.77
Corrected Bayesian Information Criteria  (BICc) :         814.04
Bayesian Information Criteria             (BIC) :         807.22

Elapsed time                          (seconds) :          35.04
CPU time                              (seconds) :          84.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.063
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 45
Number of observations (DV): 176
Number of doses: 51

